Phytochemical Analysis and Cholinesterase Inhibition of Cyperus platycaulis
نویسنده
چکیده
Cyperus platycaulis is used in folk medicine in Kano, northern Nigeria, for the treatment of cold, cough, (tuberculosis), chest congestion, asthma, sneezing, and catarrh. The tuberous fragrant herb (black species) was extracted using ethanol, chloroform, n-butane, and n-hexane, to determine the physico-chemical properties of the plant and the cytotoxicity of the extracts with reference to its anti-bacterial (anti-tuberculea) properties. Fractionation of the crude compounds followed by phytochemical screening, anti-cholinesterase (enzyme estimation) activity, and inhibition of sheep liver by the extracts are reported. Ethanol and n-butane extracts were positive for nearly all bioactive compounds tested. Chloroform and nhexane extracts were both negative for carbohydrates, tannins, and glycosides. Alkaloids were completely absent. Cholinesterase inhibition of the extracts was encouraging. The order of ChE inhibition, (percentage inhibition of ChE over control) from highest to least was FE001 (72.4%), > FC001 (66.5%), > FB001 (66.2%), and >FH001 (60.3%). This correlates ethnomedical claims and thus provides for the first time, the pharmacological basis for the folkloric usage of Cyperus platycaulis as a potential cure for tuberculosis in Kano State, Northern Nigeria. (
منابع مشابه
Phytochemical Screening and Biological Evaluations of Garcinia atroviridis
Garcinia atroviridis (Clusiaceae) has been used as a postpartum medication agent in folkloric medicine. However, its biological potential has not been fully evaluated. The present study was aimed to evaluate the antioxidant efficacies, cholinesterase enzyme inhibitory and antimicrobial activity of the stem bark extracts of G. atroviridis. Successive extraction was done using solvents of varied ...
متن کاملPhytochemical analysis of Cyperus rotundus hexane fraction by GC-MS and total oligomeric flavonoid fraction by 4D GCXGC TOF-MS
Cyperus rotundus (CR) is a traditional medicinal herb, and recent studies demonstrated its pharmacological effects to cure neurological disorders. In our earlier reports, we also found that CR exerts anxiolytic effects and improves memory impairment in hypoxia-induced rats. In vitro CR also effectively ameliorates oxidative stress-induced SH-SY5Y neuronal cell damage. In the present study, we e...
متن کاملSynthesis, X-Rays Analysis, Docking Study and Cholinesterase Inhibition Activity of 2,3-dihydroquinazolin-4(1H)-one Derivatives
In search of potent cholinesterase inhibitors, we have carried out the synthesis and biologically evaluation of various benzaldehyde based 2,3-dihydroquinazolin-4(1H)-one derivatives. In vitro assay results revealed that all the synthesized compounds showed activity against both enzymes (AChE and BChE) and in few cases, the inhibition activity was even higher than or comp...
متن کاملAuthor's response to reviews Title:Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L. Authors:
متن کامل
A NEW PENTACYCLIC TRITERPENOID WITH ANTIMICROBIAL ACTIVITY FROM THE TUBERS OF Cyperus rotundus Linn
Outcome: Phytochemical investigation of Cyperus rotundus tubers resulted in isolation of four phytoconstituents characterized as n-tritriacontan-16-one (1), Lup-12, 20 (29)-dien-3β-ol-3-α-L-arabinofuranosyl-2'-octadec-9"-eonate (2), npentadecanyl-9-octadecenoate (3) and n-tetradecanyl-n-octadec-9, 12-dienoate (4). Only compound 2 showed antimicrobial activity. Lup-12, 20 (29)-dien-3β-ol3-α-L-ar...
متن کامل